Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
c3a.1Complement component c3a, duplicate 1. (1643 aa)    
Predicted Functional Partners:
cfhl1
Complement factor H-like 1.
   
 0.865
F1QJB3_DANRE
Si:ch1073-280e3.1; Belongs to the peptidase S1 family.
   
 0.838
cfi
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 0.827
cfb
Complement factor B; Belongs to the peptidase S1 family.
   
 0.818
c9
Complement component 9.
   
 0.808
c5ar1
C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Belongs to the G-protein coupled receptor 1 family.
    
 0.796
A9C4A2_DANRE
Si:ch73-237c6.1.
   
 0.783
C3AR1
C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity); Belongs to the G-protein coupled receptor 1 family.
    
 0.779
c5
Complement component 5.
   
0.779
cfp
Complement factor properdin.
   
 0.760
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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