STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acta1aActin alpha 1, skeletal muscle a. (377 aa)    
Predicted Functional Partners:
tpm4b
Tropomyosin 4b.
   
 0.873
myh7
Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.864
tpm3
Tropomyosin 3; Belongs to the tropomyosin family.
   
 0.861
tpma
Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family.
   
 0.848
dctn2
Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity).
   
 0.832
myl1
Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.
   
 
 0.831
actr10
Actin-related protein 10; Belongs to the actin family.
   
0.823
myh7l
Myosin heavy chain 7-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.815
myh6
Myosin, heavy chain 6, cardiac muscle, alpha; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.810
tpm2
Tropomyosin 2 (beta); Belongs to the tropomyosin family.
   
 0.810
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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