Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
acta1aActin alpha 1, skeletal muscle a. (377 aa)    
Predicted Functional Partners:
actc1c
Actin alpha cardiac muscle 1a.
  
 
0.952
acta1b
Actin alpha 1, skeletal muscle b.
  
 
0.914
actc1a
Actin, alpha, cardiac muscle 1a.
  
 
0.914
zgc:86709
Novel actin protein.
  
  
0.914
actc1b
Actin, alpha 1, skeletal muscle.
  
 
0.914
ENSDARP00000100434
Actin alpha cardiac muscle 1a.
  
 
 
0.901
acta2
Actin, alpha 2, smooth muscle, aorta.
  
 
 
0.901
tnnt2e
Novel slow skeletal troponin T family protein.
   
  0.856
X1WCU6_DANRE
Profilin; Belongs to the profilin family.
   
 0.816
arpc2
Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
   
 0.803
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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