Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Q1L8U9_DANRESi:ch211-81a5.5. (481 aa)    
Predicted Functional Partners:
lypd6b
LY6/PLAUR domain-containing 6B.
   
  
 0.642
pear1
Platelet endothelial aggregation receptor 1.
      
 0.619
nme8
NME/NM23 family member 8; Belongs to the NDK family.
    
 
 0.462
tctex1d1
Tctex1 domain-containing protein 1; Belongs to the dynein light chain Tctex-type family.
   
 
 0.460
daw1
Dynein assembly factor with WDR repeat domains 1; Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis.
   
  
 0.448
lypd6
Ly6/PLAUR domain-containing protein 6; Acts as an important regulator of embryogenesis through its enhancement of Wnt/beta-catenin signaling. Positively regulates Wnt/beta-catenin signaling by ensuring phosphorylation of lrp6 specifically in plasma membrane rafts and its subsequent internalization into signaling-competent vesicles. Essential for the wnt8-mediated patterning of the mesoderm and neuroectoderm during gastrulation.
   
  
 0.417
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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