Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (757 aa)    
Predicted Functional Partners:
lrch4
Leucine-rich repeats and calponin homology (CH) domain-containing 4.
   
  
 0.771
rabgap1l
RAB GTPase-activating protein 1-like.
    
 
 0.720
appl2
Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper-containing 2.
   
 0.657
appl1
HESX homeobox 1.
   
 0.657
gnb2
Guanine nucleotide-binding protein (G protein), beta polypeptide 2.
      
 0.609
cars2
Cysteinyl-tRNA synthetase 2, mitochondrial.
      
 0.589
arfgap1
ADP-ribosylation factor GTPase-activating protein 1.
    
 0.579
slc6a14
Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
      
 0.547
ctdnep1a
CTD nuclear envelope phosphatase 1A; Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity); Belong [...]
      
 0.545
ctdnep1b
CTD nuclear envelope phosphatase 1B; Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity); Belong [...]
      
 0.545
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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