Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hexim1Protein HEXIM; Probable transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor; Belongs to the HEXIM family. (319 aa)    
Predicted Functional Partners:
larp7
La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
   
 
 0.996
cdk9
Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.
    
 
 0.995
mepce
7SK snRNA methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
    
 
 0.989
ccnt1
Cyclin T1; Belongs to the cyclin family.
    
 
 0.980
MEPCE
Si:ch1073-157b13.1.
   
 
 0.974
ccnt2a
Cyclin T2a; Belongs to the cyclin family.
    
 
 0.934
aff4
AF4/FMR2 family, member 4.
    
 
 0.902
ccnt2b
Zgc:55690 protein; Belongs to the cyclin family.
   
 
 0.884
srsf10b
Serine and arginine-rich-splicing factor 10b.
    
 
 0.854
ENSDARP00000150264
RRM domain-containing protein.
    
 
 0.854
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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