| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SPHK1 | s1pr1 | ENSDARP00000132891 | ENSDARP00000062632 | Sphingosine kinase 1. | Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. | 0.514 |
| SPHK1 | s1pr2 | ENSDARP00000132891 | ENSDARP00000053105 | Sphingosine kinase 1. | Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). | 0.817 |
| SPHK1 | s1pr3a | ENSDARP00000132891 | ENSDARP00000113862 | Sphingosine kinase 1. | Sphingosine-1-phosphate receptor 3a; Belongs to the G-protein coupled receptor 1 family. | 0.687 |
| SPHK1 | s1pr4 | ENSDARP00000132891 | ENSDARP00000112534 | Sphingosine kinase 1. | Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.593 |
| SPHK1 | s1pr5b | ENSDARP00000132891 | ENSDARP00000125952 | Sphingosine kinase 1. | Sphingosine-1-phosphate receptor 5b. | 0.481 |
| SPHK1 | sphk2 | ENSDARP00000132891 | ENSDARP00000131179 | Sphingosine kinase 1. | Sphingosine kinase 2. | 0.944 |
| gna12a | gnaq | ENSDARP00000050331 | ENSDARP00000020119 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Guanine nucleotide-binding protein (G protein), q polypeptide. | 0.935 |
| gna12a | s1pr1 | ENSDARP00000050331 | ENSDARP00000062632 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. | 0.650 |
| gna12a | s1pr2 | ENSDARP00000050331 | ENSDARP00000053105 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). | 0.903 |
| gna12a | s1pr3a | ENSDARP00000050331 | ENSDARP00000113862 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Sphingosine-1-phosphate receptor 3a; Belongs to the G-protein coupled receptor 1 family. | 0.812 |
| gna12a | s1pr4 | ENSDARP00000050331 | ENSDARP00000112534 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.821 |
| gna12a | s1pr5a | ENSDARP00000050331 | ENSDARP00000115650 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Sphingosine-1-phosphate receptor 5a; Belongs to the G-protein coupled receptor 1 family. | 0.567 |
| gna12a | s1pr5b | ENSDARP00000050331 | ENSDARP00000125952 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Sphingosine-1-phosphate receptor 5b. | 0.695 |
| gna12a | sphk2 | ENSDARP00000050331 | ENSDARP00000131179 | Guanine nucleotide-binding protein (G protein) alpha 12a. | Sphingosine kinase 2. | 0.409 |
| gnaq | gna12a | ENSDARP00000020119 | ENSDARP00000050331 | Guanine nucleotide-binding protein (G protein), q polypeptide. | Guanine nucleotide-binding protein (G protein) alpha 12a. | 0.935 |
| gnaq | s1pr1 | ENSDARP00000020119 | ENSDARP00000062632 | Guanine nucleotide-binding protein (G protein), q polypeptide. | Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. | 0.667 |
| gnaq | s1pr2 | ENSDARP00000020119 | ENSDARP00000053105 | Guanine nucleotide-binding protein (G protein), q polypeptide. | Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). | 0.848 |
| gnaq | s1pr3a | ENSDARP00000020119 | ENSDARP00000113862 | Guanine nucleotide-binding protein (G protein), q polypeptide. | Sphingosine-1-phosphate receptor 3a; Belongs to the G-protein coupled receptor 1 family. | 0.696 |
| gnaq | s1pr4 | ENSDARP00000020119 | ENSDARP00000112534 | Guanine nucleotide-binding protein (G protein), q polypeptide. | Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.433 |
| gnaq | s1pr5a | ENSDARP00000020119 | ENSDARP00000115650 | Guanine nucleotide-binding protein (G protein), q polypeptide. | Sphingosine-1-phosphate receptor 5a; Belongs to the G-protein coupled receptor 1 family. | 0.589 |
