| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| nrp1a | plxna1a | ENSDARP00000140900 | ENSDARP00000142340 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin A1a. | 0.804 |
| nrp1a | plxna2 | ENSDARP00000140900 | ENSDARP00000152904 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin A2. | 0.914 |
| nrp1a | plxna3 | ENSDARP00000140900 | ENSDARP00000043999 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. | 0.929 |
| nrp1a | plxna4 | ENSDARP00000140900 | ENSDARP00000021195 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin-A4; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons. | 0.933 |
| nrp1a | plxnb1b | ENSDARP00000140900 | ENSDARP00000131217 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin b1b. | 0.661 |
| nrp1a | plxnc1 | ENSDARP00000140900 | ENSDARP00000115802 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin C1. | 0.612 |
| nrp1a | plxnd1 | ENSDARP00000140900 | ENSDARP00000112069 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin D1. | 0.864 |
| nrp1a | sema3e | ENSDARP00000140900 | ENSDARP00000053124 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. | 0.908 |
| nrp1a | sema3fa | ENSDARP00000140900 | ENSDARP00000046497 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. | 0.896 |
| nrp1b | plxna1a | ENSDARP00000089037 | ENSDARP00000142340 | Neuropilin 1b. | Plexin A1a. | 0.578 |
| nrp1b | plxna2 | ENSDARP00000089037 | ENSDARP00000152904 | Neuropilin 1b. | Plexin A2. | 0.666 |
| nrp1b | plxna3 | ENSDARP00000089037 | ENSDARP00000043999 | Neuropilin 1b. | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. | 0.683 |
| nrp1b | plxna4 | ENSDARP00000089037 | ENSDARP00000021195 | Neuropilin 1b. | Plexin-A4; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons. | 0.693 |
| nrp1b | plxnb1b | ENSDARP00000089037 | ENSDARP00000131217 | Neuropilin 1b. | Plexin b1b. | 0.430 |
| nrp1b | plxnd1 | ENSDARP00000089037 | ENSDARP00000112069 | Neuropilin 1b. | Plexin D1. | 0.743 |
| nrp1b | sema3e | ENSDARP00000089037 | ENSDARP00000053124 | Neuropilin 1b. | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. | 0.727 |
| nrp1b | sema3fa | ENSDARP00000089037 | ENSDARP00000046497 | Neuropilin 1b. | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. | 0.569 |
| plxna1a | nrp1a | ENSDARP00000142340 | ENSDARP00000140900 | Plexin A1a. | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | 0.804 |
| plxna1a | nrp1b | ENSDARP00000142340 | ENSDARP00000089037 | Plexin A1a. | Neuropilin 1b. | 0.578 |
| plxna1a | plxna2 | ENSDARP00000142340 | ENSDARP00000152904 | Plexin A1a. | Plexin A2. | 0.903 |
