Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
stk35lSerine/threonine kinase 35,-like; Belongs to the protein kinase superfamily. (397 aa)    
Predicted Functional Partners:
rb1cc1
RB1-inducible coiled-coil 1.
   
 0.783
atg13
Autophagy-related protein 13; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.
   
 0.762
pik3r4
Phosphoinositide-3-kinase, regulatory subunit 4.
    
 0.762
pik3c3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 0.762
becn1
Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...]
    
 0.761
atg101
Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Belongs to the ATG101 family.
    
 0.745
sema4bb
Semaphorin-4B; Belongs to the semaphorin family.
      
 0.734
MANEAL
Glycoprotein endo-alpha-1,2-mannosidase-like protein.
      
 0.719
atg2b
Autophagy-related 2B.
   
 0.703
ATG2A
Si:ch73-45o6.2.
   
 0.703
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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