Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rcbtb1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain-containing protein 1. (531 aa)    
Predicted Functional Partners:
znf408
Zinc finger protein 408.
    
 0.893
cdadc1
Cytidine and dCMP deaminase domain-containing protein 1.
 
    
 0.797
llph
Protein LLP homolog; Regulates dendritic and spine growth and synaptic transmission; Belongs to the learning-associated protein family.
      
 0.782
tspan12
Tetraspanin.
      
 0.780
kif11
Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
    
 
 0.731
phf11
PHD finger protein 11.
      
 0.720
ddx55
ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. Plays an essential role in early embryonic development; Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
   
 
 0.684
ercc6l
DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
    
 
 0.674
cul3a
Cullin 3a; Belongs to the cullin family.
    
 0.671
cul3b
Cullin 3b; Belongs to the cullin family.
    
 0.671
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.