node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT12 | aldh8a1 | ENSDARP00000071202 | ENSDARP00000053398 | Acyl-CoA thioesterase 12. | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | 0.694 |
ACOT12 | gramd2aa | ENSDARP00000071202 | ENSDARP00000130256 | Acyl-CoA thioesterase 12. | GRAM domain-containing 2Aa. | 0.869 |
ACOT12 | suclg2 | ENSDARP00000071202 | ENSDARP00000107576 | Acyl-CoA thioesterase 12. | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.821 |
acmsd | aldh8a1 | ENSDARP00000114101 | ENSDARP00000053398 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | 0.966 |
adhfe1 | aldh18a1 | ENSDARP00000070033 | ENSDARP00000137162 | Alcohol dehydrogenase iron-containing 1. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.621 |
adhfe1 | aldh8a1 | ENSDARP00000070033 | ENSDARP00000053398 | Alcohol dehydrogenase iron-containing 1. | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | 0.822 |
adhfe1 | hbs1l | ENSDARP00000070033 | ENSDARP00000118572 | Alcohol dehydrogenase iron-containing 1. | HBS1-like translational GTPase. | 0.544 |
adhfe1 | hsdl2 | ENSDARP00000070033 | ENSDARP00000038205 | Alcohol dehydrogenase iron-containing 1. | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.945 |
aldh18a1 | adhfe1 | ENSDARP00000137162 | ENSDARP00000070033 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Alcohol dehydrogenase iron-containing 1. | 0.621 |
aldh18a1 | aldh8a1 | ENSDARP00000137162 | ENSDARP00000053398 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | 0.726 |
aldh18a1 | ephx2 | ENSDARP00000137162 | ENSDARP00000058889 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Epoxide hydrolase 2, cytoplasmic. | 0.616 |
aldh18a1 | hsdl2 | ENSDARP00000137162 | ENSDARP00000038205 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.764 |
aldh18a1 | suclg2 | ENSDARP00000137162 | ENSDARP00000107576 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.773 |
aldh8a1 | ACOT12 | ENSDARP00000053398 | ENSDARP00000071202 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | Acyl-CoA thioesterase 12. | 0.694 |
aldh8a1 | acmsd | ENSDARP00000053398 | ENSDARP00000114101 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. | 0.966 |
aldh8a1 | adhfe1 | ENSDARP00000053398 | ENSDARP00000070033 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | Alcohol dehydrogenase iron-containing 1. | 0.822 |
aldh8a1 | aldh18a1 | ENSDARP00000053398 | ENSDARP00000137162 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.726 |
aldh8a1 | ephx2 | ENSDARP00000053398 | ENSDARP00000058889 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | Epoxide hydrolase 2, cytoplasmic. | 0.846 |
aldh8a1 | gramd2aa | ENSDARP00000053398 | ENSDARP00000130256 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | GRAM domain-containing 2Aa. | 0.715 |
aldh8a1 | hbs1l | ENSDARP00000053398 | ENSDARP00000118572 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. | HBS1-like translational GTPase. | 0.728 |