STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfn2lProfilin; Belongs to the profilin family. (139 aa)    
Predicted Functional Partners:
acta1b
Actin alpha 1, skeletal muscle b.
   
 
 0.976
actb1
Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
   
 0.942
actb2
Actin, cytoplasmic 2, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
   
 0.941
vaspb
Vasodilator-stimulated phosphoprotein b.
   
 0.934
diaph2
Diaphanous-related formin 2.
    
 0.929
LOC101882228
FH2 domain-containing protein.
    
 0.929
cfl1
Muscle cofilin 2; Belongs to the actin-binding proteins ADF family.
   
 
 0.928
cfl1l
Cofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family.
   
 
 0.908
cfl2
Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.
   
 
 0.908
pfn2
Profilin; Belongs to the profilin family.
  
 
 
0.907
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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