STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnf41E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. (318 aa)    
Predicted Functional Partners:
usp8
Ubiquitin-specific peptidase 8; Belongs to the peptidase C19 family.
    
 0.984
erbb3b
Erb-b2 receptor tyrosine kinase 3b.
    
 0.944
usp2b
Ubiquitin carboxyl-terminal hydrolase.
    
 
 0.856
asb6
Ankyrin repeat and SOCS box-containing 6.
   
 
 0.805
vps52
VPS52 subunit of GARP complex.
   
 
 0.793
egfra
Epidermal growth factor receptor precursor.
    
 0.758
clec16a
C-type lectin domain-containing 16A.
   
 
 0.755
birc6
Baculoviral IAP repeat-containing 6.
    
 
 0.731
fgfr3
Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...]
     
 0.690
igf1ra
Tyrosine-protein kinase receptor.
   
 0.682
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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