Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tcf21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa)    
Predicted Functional Partners:
tbx18
T-box transcription factor 18.
      
 0.957
wt1a
WT1 transcription factor a.
   
 
 0.925
postnb
Periostin, osteoblast-specific factor b.
      
 0.798
myl7
Myosin, light polypeptide 7, regulatory.
   
  
 0.794
aldh1a2
Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family.
      
 0.784
sema3d
Semaphorin-3D; May play a role in the guidance of several axon pathways.
      
 0.720
gata4
GATA-binding protein 4.
   
 
 0.710
postna
Periostin, osteoblast-specific factor a.
      
 0.701
wt1b
WT1 transcription factor b.
   
 
 0.680
tbpl1
TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.
      
 0.667
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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