Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
irak1bp1Interleukin-1 receptor-associated kinase 1-binding protein 1 homolog; May be part of a signaling pathway that leads to NF-kappa-B activation; Belongs to the IRAK1BP1 family. (249 aa)    
Predicted Functional Partners:
ccnc
Cyclin C; Belongs to the cyclin family.
      
 0.744
il17rd
Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation.
      
 0.722
LOC101882195
Uncharacterized protein.
      
 0.717
ibtk
Inhibitor of Bruton agammaglobulinemia tyrosine kinase.
      
 0.717
ahsg1
Alpha-2-HS-glycoprotein 1.
      
 0.616
ahsg2
Alpha-2-HS-glycoprotein 2.
      
 0.616
AMDHD1
Probable imidazolonepropionase.
      
 0.609
cdk20
Cyclin-dependent kinase 20; Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
   
  
 0.609
lrrc23
Leucine-rich repeat-containing 23.
   
  
 0.607
E7EYT9_DANRE
Si:ch211-207e14.4.
      
 0.607
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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