Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ddrgk1DDRGK domain-containing protein 1; By regulating the post-translational modification of specific proteins, may play a role in different cellular process (By similarity). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator. (124 aa)    
Predicted Functional Partners:
ufl1
E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family.
   
 
 0.996
ufc1
Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm1 via a thioester linkage.
   
 
 0.995
cdk5rap3
CDK5 regulatory subunit-associated protein 3.
   
 
 0.993
ufm1
Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. Belongs to the UFM1 family.
    
 
 0.989
srpra
SRP receptor subunit alpha.
    
 
 0.939
srprb
SRP receptor subunit beta.
   
 
 0.862
uba5
Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1 and sumo2.
      
 0.842
rpl26
ATPase H+ transporting V0 subunit e1.
    
 
 0.841
thnsl2
Threonine synthase-like 2; Acts as a catabolic phospho-lyase on both gamma- and beta- phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). Belongs to the threonine synthase family.
      
 0.750
ptpra
Receptor-type tyrosine-protein phosphatase alpha.
      
 0.743
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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