zic2b protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

zic2b

ZIC family member 2 (Odd-paired homolog, Drosophila) B. (427 aa)

Predicted Functional Partners:

tgif1

0.802

ephb1

0.798

six3a

0.782

six3b

0.780

shha

0.728

isl2a

0.614

sox3

0.612

otx2b

0.589

foxd3

0.584

pax3a

0.566

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ephb1	isl2a	ENSDARP00000111570	ENSDARP00000020636	EPH receptor B1.	Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons.	0.609
ephb1	zic2b	ENSDARP00000111570	ENSDARP00000054065	EPH receptor B1.	ZIC family member 2 (Odd-paired homolog, Drosophila) B.	0.798
foxd3	pax3a	ENSDARP00000107660	ENSDARP00000037761	Forkhead box D3.	Transcription factor PAX3.	0.930
foxd3	shha	ENSDARP00000107660	ENSDARP00000125090	Forkhead box D3.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.568
foxd3	sox3	ENSDARP00000107660	ENSDARP00000070099	Forkhead box D3.	Transcription factor Sox-3; Transcriptional activator.	0.645
foxd3	zic2b	ENSDARP00000107660	ENSDARP00000054065	Forkhead box D3.	ZIC family member 2 (Odd-paired homolog, Drosophila) B.	0.584
isl2a	ephb1	ENSDARP00000020636	ENSDARP00000111570	Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons.	EPH receptor B1.	0.609
isl2a	shha	ENSDARP00000020636	ENSDARP00000125090	Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.464
isl2a	zic2b	ENSDARP00000020636	ENSDARP00000054065	Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons.	ZIC family member 2 (Odd-paired homolog, Drosophila) B.	0.614
otx2b	shha	ENSDARP00000111153	ENSDARP00000125090	Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.819
otx2b	six3a	ENSDARP00000111153	ENSDARP00000075254	Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.	Sine oculis homeobox homolog 3a.	0.900
otx2b	six3b	ENSDARP00000111153	ENSDARP00000071625	Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.	Sine oculis homeobox homolog 3b.	0.903
otx2b	sox3	ENSDARP00000111153	ENSDARP00000070099	Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.	Transcription factor Sox-3; Transcriptional activator.	0.678
otx2b	zic2b	ENSDARP00000111153	ENSDARP00000054065	Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.	ZIC family member 2 (Odd-paired homolog, Drosophila) B.	0.589
pax3a	foxd3	ENSDARP00000037761	ENSDARP00000107660	Transcription factor PAX3.	Forkhead box D3.	0.930
pax3a	shha	ENSDARP00000037761	ENSDARP00000125090	Transcription factor PAX3.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.736
pax3a	six3a	ENSDARP00000037761	ENSDARP00000075254	Transcription factor PAX3.	Sine oculis homeobox homolog 3a.	0.426
pax3a	six3b	ENSDARP00000037761	ENSDARP00000071625	Transcription factor PAX3.	Sine oculis homeobox homolog 3b.	0.426
pax3a	sox3	ENSDARP00000037761	ENSDARP00000070099	Transcription factor PAX3.	Transcription factor Sox-3; Transcriptional activator.	0.525
pax3a	zic2b	ENSDARP00000037761	ENSDARP00000054065	Transcription factor PAX3.	ZIC family member 2 (Odd-paired homolog, Drosophila) B.	0.566

page 1 of 4

Server load: low (20%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About