Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
tpbgbWnt-activated inhibitory factor 1c. (382 aa)    
Predicted Functional Partners:
nabp1a
SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity).
      
 0.561
oplah
5-oxoprolinase, ATP-hydrolysing.
      
 0.541
cdh19
Uncharacterized protein.
      
 0.490
otogl
Otogelin-like.
   
 0.465
SGCZ
Sarcoglycan zeta.
      
 0.461
fmn1
Formin 1.
    
 
 0.446
lrrc3
Leucine-rich repeat-containing protein 3.
     
 0.445
tsku
Tsukushin; Dorsalizing factor. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation.
      
 0.438
cbln2a
Cerebellin 2a precursor.
    
 
 0.434
parp3
Poly [ADP-ribose] polymerase.
    
 
 0.426
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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