mtap protein (Danio rerio) - STRING interaction network

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mtap

S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (280 aa)

Predicted Functional Partners:

srm

0.982

sms

0.973

mri1

0.967

lacc1

0.952

riok1

0.863

prmt5

0.812

mbtps2

0.803

ephx2

0.797

cdkn2a/b

0.747

accs

0.740

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
accs	mtap	ENSDARP00000106346	ENSDARP00000054207	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional).	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.740
accs	sms	ENSDARP00000106346	ENSDARP00000100321	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional).	Spermine synthase.	0.753
accs	srm	ENSDARP00000106346	ENSDARP00000072618	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional).	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.768
cdkn2a/b	mtap	ENSDARP00000145630	ENSDARP00000054207	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4).	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.747
ephx2	lacc1	ENSDARP00000058889	ENSDARP00000099363	Epoxide hydrolase 2, cytoplasmic.	Laccase (multicopper oxidoreductase) domain-containing 1.	0.777
ephx2	mtap	ENSDARP00000058889	ENSDARP00000054207	Epoxide hydrolase 2, cytoplasmic.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.797
ephx2	sms	ENSDARP00000058889	ENSDARP00000100321	Epoxide hydrolase 2, cytoplasmic.	Spermine synthase.	0.422
lacc1	ephx2	ENSDARP00000099363	ENSDARP00000058889	Laccase (multicopper oxidoreductase) domain-containing 1.	Epoxide hydrolase 2, cytoplasmic.	0.777
lacc1	mbtps2	ENSDARP00000099363	ENSDARP00000096598	Laccase (multicopper oxidoreductase) domain-containing 1.	Membrane-bound transcription factor peptidase, site 2.	0.826
lacc1	mri1	ENSDARP00000099363	ENSDARP00000098757	Laccase (multicopper oxidoreductase) domain-containing 1.	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	0.952
lacc1	mtap	ENSDARP00000099363	ENSDARP00000054207	Laccase (multicopper oxidoreductase) domain-containing 1.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.952
lacc1	sms	ENSDARP00000099363	ENSDARP00000100321	Laccase (multicopper oxidoreductase) domain-containing 1.	Spermine synthase.	0.946
lacc1	srm	ENSDARP00000099363	ENSDARP00000072618	Laccase (multicopper oxidoreductase) domain-containing 1.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.951
mbtps2	lacc1	ENSDARP00000096598	ENSDARP00000099363	Membrane-bound transcription factor peptidase, site 2.	Laccase (multicopper oxidoreductase) domain-containing 1.	0.826
mbtps2	mtap	ENSDARP00000096598	ENSDARP00000054207	Membrane-bound transcription factor peptidase, site 2.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.803
mbtps2	sms	ENSDARP00000096598	ENSDARP00000100321	Membrane-bound transcription factor peptidase, site 2.	Spermine synthase.	0.591
mbtps2	srm	ENSDARP00000096598	ENSDARP00000072618	Membrane-bound transcription factor peptidase, site 2.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.822
mri1	lacc1	ENSDARP00000098757	ENSDARP00000099363	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	Laccase (multicopper oxidoreductase) domain-containing 1.	0.952
mri1	mtap	ENSDARP00000098757	ENSDARP00000054207	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.967
mri1	srm	ENSDARP00000098757	ENSDARP00000072618	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	Spermidine synthase; Belongs to the spermidine/spermine synthase family.	0.546

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