Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
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[Homology]
Score
fggFibrinogen, gamma polypeptide. (431 aa)    
Predicted Functional Partners:
fgb
Fibrinogen, B beta polypeptide.
   
0.999
fga
Fibrinogen alpha chain.
   
0.999
f2
Coagulation factor II (thrombin); Belongs to the peptidase S1 family.
   
 0.992
plg
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
   
 
 0.938
ahsg1
Alpha-2-HS-glycoprotein 1.
   
 
 0.903
ahsg2
Alpha-2-HS-glycoprotein 2.
   
 0.902
serpind1
Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.
   
 0.880
ambp
Alpha-1-microglobulin/bikunin precursor.
   
  
 0.871
serpinc1
Serine (Or cysteine) proteinase inhibitor, clade C (Antithrombin), member 1; Belongs to the serpin family.
   
 0.870
itga2b
Integrin, alpha 2b (Platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B); Belongs to the integrin alpha chain family.
    
 0.859
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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