node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
crhb | fosab | ENSDARP00000038676 | ENSDARP00000043297 | Corticotropin-releasing hormone b. | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | 0.762 |
crhb | nr3c1 | ENSDARP00000038676 | ENSDARP00000054263 | Corticotropin-releasing hormone b. | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). | 0.886 |
fkbp5 | hsp90aa1.1 | ENSDARP00000038578 | ENSDARP00000022302 | Peptidylprolyl isomerase. | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] | 0.850 |
fkbp5 | hsp90ab1 | ENSDARP00000038578 | ENSDARP00000014978 | Peptidylprolyl isomerase. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.836 |
fkbp5 | nr3c1 | ENSDARP00000038578 | ENSDARP00000054263 | Peptidylprolyl isomerase. | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). | 0.856 |
fkbp5 | ptges3a | ENSDARP00000038578 | ENSDARP00000054236 | Peptidylprolyl isomerase. | Prostaglandin E synthase 3a (cytosolic). | 0.940 |
fkbp5 | stip1 | ENSDARP00000038578 | ENSDARP00000100503 | Peptidylprolyl isomerase. | Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein). | 0.836 |
fosab | crhb | ENSDARP00000043297 | ENSDARP00000038676 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Corticotropin-releasing hormone b. | 0.762 |
fosab | nr3c1 | ENSDARP00000043297 | ENSDARP00000054263 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). | 0.818 |
hsp90aa1.1 | fkbp5 | ENSDARP00000022302 | ENSDARP00000038578 | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] | Peptidylprolyl isomerase. | 0.850 |
hsp90aa1.1 | hsp90ab1 | ENSDARP00000022302 | ENSDARP00000014978 | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.902 |
hsp90aa1.1 | nr3c1 | ENSDARP00000022302 | ENSDARP00000054263 | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). | 0.893 |
hsp90aa1.1 | ptges3a | ENSDARP00000022302 | ENSDARP00000054236 | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] | Prostaglandin E synthase 3a (cytosolic). | 0.917 |
hsp90aa1.1 | stip1 | ENSDARP00000022302 | ENSDARP00000100503 | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] | Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein). | 0.962 |
hsp90ab1 | fkbp5 | ENSDARP00000014978 | ENSDARP00000038578 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Peptidylprolyl isomerase. | 0.836 |
hsp90ab1 | hsp90aa1.1 | ENSDARP00000014978 | ENSDARP00000022302 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] | 0.902 |
hsp90ab1 | nr3c1 | ENSDARP00000014978 | ENSDARP00000054263 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). | 0.835 |
hsp90ab1 | ptges3a | ENSDARP00000014978 | ENSDARP00000054236 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Prostaglandin E synthase 3a (cytosolic). | 0.985 |
hsp90ab1 | stip1 | ENSDARP00000014978 | ENSDARP00000100503 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein). | 0.983 |
ncoa1 | ncoa2 | ENSDARP00000111627 | ENSDARP00000107210 | Nuclear receptor coactivator 1. | Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages. May play a role in the positive regulation of the circadian clock (By similarity). | 0.909 |