Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
il10rbInterleukin 10 receptor, beta. (367 aa)    
Predicted Functional Partners:
il10
Interleukin-10.
    
 0.996
tyk2
Tyrosine-protein kinase.
   
 0.992
ifngr2
Interferon gamma receptor 2.
   
 
 0.991
crfb2
Cytokine receptor family member b2.
    
 0.991
il10ra
Interleukin 10 receptor, alpha.
     
 0.991
il22
Interleukin 22.
     
 0.985
ifngr1
Interferon gamma receptor 1.
     
 0.981
crfb1
Cytokine receptor family member b1.
    
 0.979
jak1
Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.
   
 0.978
crfb4
Cytokine receptor family member b4.
     
0.974
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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