STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tlr2Toll-like receptor 2. (788 aa)    
Predicted Functional Partners:
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response.
   
 0.999
tlr1
Toll-like receptor 1; Belongs to the Toll-like receptor family.
  
 
0.996
tirap
Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein.
   
 0.993
tollip
Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
    
 0.982
tlr18
Toll-like receptor 18.
     
0.951
il10
Interleukin-10.
   
 
 0.935
nod2
Nucleotide-binding oligomerization domain-containing 2.
   
 0.895
tnfb
Tumor necrosis factor b (TNF superfamily, member 2).
   
 
 0.887
hmgb1a
High mobility group box 1a.
   
 0.857
nod1
Nucleotide-binding oligomerization domain-containing 1.
    
 0.831
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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