Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rybpaRING1 and YY1-binding protein A; May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. (384 aa)    
Predicted Functional Partners:
rnf2
E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...]
    
 
 0.947
pcgf1
Polycomb group RING finger protein 1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
    
 
 0.899
pcgf6
Polycomb group ring finger 6.
    
 
 0.881
cbx2
Chromobox homolog 2 (Drosophila Pc class).
    
 
 0.826
l3mbtl2
L3MBTL histone methyl-lysine-binding protein 2.
   
 
 0.800
LOC100536129
Lysine (K)-specific demethylase 2Bb.
    
 
 0.780
kdm2aa
Lysine (K)-specific demethylase 2Aa.
    
 
 0.780
zgc:158376
Zgc:158376.
    
 
 0.780
kdm2ab
Lysine (K)-specific demethylase 2Ab.
    
 
 0.780
kdm2ba
Lysine (K)-specific demethylase 2Ba.
    
 
 0.780
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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