phlda3 protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

phlda3

Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity). (127 aa)

Predicted Functional Partners:

inka2

0.734

ccng1

0.717

fibina

0.684

b4galnt3b

0.682

c2cd5

0.682

prr33

0.682

nupr1a

0.662

gadd45aa

0.658

isg20

0.629

stk31

0.609

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
b4galnt3b	c2cd5	ENSDARP00000102026	ENSDARP00000115392	Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.	C2 calcium-dependent domain-containing 5.	0.982
b4galnt3b	phlda3	ENSDARP00000102026	ENSDARP00000055086	Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.682
b4galnt3b	prr33	ENSDARP00000102026	ENSDARP00000127713	Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.	Proline-rich 33.	0.960
c2cd5	b4galnt3b	ENSDARP00000115392	ENSDARP00000102026	C2 calcium-dependent domain-containing 5.	Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.	0.982
c2cd5	phlda3	ENSDARP00000115392	ENSDARP00000055086	C2 calcium-dependent domain-containing 5.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.682
c2cd5	prr33	ENSDARP00000115392	ENSDARP00000127713	C2 calcium-dependent domain-containing 5.	Proline-rich 33.	0.960
ccng1	inka2	ENSDARP00000101848	ENSDARP00000141219	Cyclin G1; Belongs to the cyclin family.	Inka box actin regulator 2.	0.579
ccng1	phlda3	ENSDARP00000101848	ENSDARP00000055086	Cyclin G1; Belongs to the cyclin family.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.717
fibina	phlda3	ENSDARP00000058442	ENSDARP00000055086	Fin bud initiation factor a.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.684
gadd45aa	isg20	ENSDARP00000063995	ENSDARP00000128266	Growth arrest and DNA-damage-inducible, alpha, a.	Interferon-stimulated exonuclease gene.	0.412
gadd45aa	phlda3	ENSDARP00000063995	ENSDARP00000055086	Growth arrest and DNA-damage-inducible, alpha, a.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.658
inka2	ccng1	ENSDARP00000141219	ENSDARP00000101848	Inka box actin regulator 2.	Cyclin G1; Belongs to the cyclin family.	0.579
inka2	phlda3	ENSDARP00000141219	ENSDARP00000055086	Inka box actin regulator 2.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.734
isg20	gadd45aa	ENSDARP00000128266	ENSDARP00000063995	Interferon-stimulated exonuclease gene.	Growth arrest and DNA-damage-inducible, alpha, a.	0.412
isg20	phlda3	ENSDARP00000128266	ENSDARP00000055086	Interferon-stimulated exonuclease gene.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.629
nupr1a	phlda3	ENSDARP00000130897	ENSDARP00000055086	Nuclear protein 1a.	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	0.662
phlda3	b4galnt3b	ENSDARP00000055086	ENSDARP00000102026	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.	0.682
phlda3	c2cd5	ENSDARP00000055086	ENSDARP00000115392	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	C2 calcium-dependent domain-containing 5.	0.682
phlda3	ccng1	ENSDARP00000055086	ENSDARP00000101848	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	Cyclin G1; Belongs to the cyclin family.	0.717
phlda3	fibina	ENSDARP00000055086	ENSDARP00000058442	Pleckstrin homology-like domain family A member 3; p53/tp53-regulated repressor of Akt/akt1 signaling. Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation. Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity. Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1. May act as a tumor suppressor (By similarity).	Fin bud initiation factor a.	0.684

page 1 of 2

Server load: low (16%) [HD]

Permalink

Network

Co-occurrence

Textmining

Co-expression

Experiments

Neighborhood

Databases

Fusion

© STRING Consortium 2026

Credits

Access

Info

About