Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cdk5r1aCyclin-dependent kinase 5 activator. (306 aa)    
Predicted Functional Partners:
cdk5
Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily.
    
 0.954
snapc2
Small nuclear RNA-activating complex, polypeptide 2.
      
 0.886
zfyve9a
Zinc finger, FYVE domain-containing 9a.
      
 0.799
astn1
Astrotactin 1.
   
  
 0.785
mapta
Microtubule-associated protein.
   
 0.543
map2
Microtubule-associated protein 2.
   
 0.543
maptb
Microtubule-associated protein.
   
 0.543
neurog1
Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...]
      
 0.489
LOC101885164
Death-associated protein 1b.
   
  
 0.426
spns2
Protein spinster homolog 2; Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration ; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
      
 0.418
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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