| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fam20cb | nosip | ENSDARP00000108033 | ENSDARP00000055311 | FAM20C golgi-associated secretory pathway kinase b. | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | 0.723 |
| lrp1aa | nosip | ENSDARP00000133829 | ENSDARP00000055311 | Low density lipoprotein receptor-related protein 1Aa. | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | 0.645 |
| lrp1aa | saal1 | ENSDARP00000133829 | ENSDARP00000011636 | Low density lipoprotein receptor-related protein 1Aa. | Protein saal1; Plays a role in promoting cell proliferation in response to proinflammatory stimuli; Belongs to the SAAL1 family. | 0.802 |
| lrp1aa | tgm2l | ENSDARP00000133829 | ENSDARP00000122920 | Low density lipoprotein receptor-related protein 1Aa. | Transglutaminase 2,-like. | 0.807 |
| med25 | nosip | ENSDARP00000055392 | ENSDARP00000055311 | Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | 0.698 |
| med25 | prrg2 | ENSDARP00000055392 | ENSDARP00000128687 | Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Proline-rich Gla (G-carboxyglutamic acid) 2. | 0.852 |
| med25 | rcn3 | ENSDARP00000055392 | ENSDARP00000055323 | Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Reticulocalbin 3, EF-hand calcium-binding domain. | 0.831 |
| nosip | fam20cb | ENSDARP00000055311 | ENSDARP00000108033 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | FAM20C golgi-associated secretory pathway kinase b. | 0.723 |
| nosip | lrp1aa | ENSDARP00000055311 | ENSDARP00000133829 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Low density lipoprotein receptor-related protein 1Aa. | 0.645 |
| nosip | med25 | ENSDARP00000055311 | ENSDARP00000055392 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.698 |
| nosip | prrg2 | ENSDARP00000055311 | ENSDARP00000128687 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Proline-rich Gla (G-carboxyglutamic acid) 2. | 0.888 |
| nosip | rcn3 | ENSDARP00000055311 | ENSDARP00000055323 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Reticulocalbin 3, EF-hand calcium-binding domain. | 0.826 |
| nosip | saal1 | ENSDARP00000055311 | ENSDARP00000011636 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Protein saal1; Plays a role in promoting cell proliferation in response to proinflammatory stimuli; Belongs to the SAAL1 family. | 0.651 |
| nosip | shisa9a | ENSDARP00000055311 | ENSDARP00000066385 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Protein shisa-9A; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity). | 0.702 |
| nosip | snrnp40 | ENSDARP00000055311 | ENSDARP00000038728 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Small nuclear ribonucleoprotein 40 (U5). | 0.899 |
| nosip | stk17a | ENSDARP00000055311 | ENSDARP00000067763 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Serine/threonine kinase 17a; Belongs to the protein kinase superfamily. | 0.695 |
| nosip | tgm2l | ENSDARP00000055311 | ENSDARP00000122920 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | Transglutaminase 2,-like. | 0.652 |
| prrg2 | med25 | ENSDARP00000128687 | ENSDARP00000055392 | Proline-rich Gla (G-carboxyglutamic acid) 2. | Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.852 |
| prrg2 | nosip | ENSDARP00000128687 | ENSDARP00000055311 | Proline-rich Gla (G-carboxyglutamic acid) 2. | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). | 0.888 |
| prrg2 | rcn3 | ENSDARP00000128687 | ENSDARP00000055323 | Proline-rich Gla (G-carboxyglutamic acid) 2. | Reticulocalbin 3, EF-hand calcium-binding domain. | 0.905 |