STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nosipNitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity). (304 aa)    
Predicted Functional Partners:
snrnp40
Small nuclear ribonucleoprotein 40 (U5).
 
      0.899
prrg2
Proline-rich Gla (G-carboxyglutamic acid) 2.
      
 0.888
rcn3
Reticulocalbin 3, EF-hand calcium-binding domain.
      
 0.826
fam20cb
FAM20C golgi-associated secretory pathway kinase b.
    
 
 0.723
shisa9a
Protein shisa-9A; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).
   
  
 0.702
med25
Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
   
  
 0.698
stk17a
Serine/threonine kinase 17a; Belongs to the protein kinase superfamily.
   
  
 0.695
tgm2l
Transglutaminase 2,-like.
   
  
 0.652
saal1
Protein saal1; Plays a role in promoting cell proliferation in response to proinflammatory stimuli; Belongs to the SAAL1 family.
   
  
 0.651
lrp1aa
Low density lipoprotein receptor-related protein 1Aa.
      
 0.645
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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