STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
osr2Protein odd-skipped-related 2; Transcriptional repressor (By similarity). Required for pronephric kidney development; Belongs to the Odd C2H2-type zinc-finger protein family. (238 aa)    
Predicted Functional Partners:
fam20b
Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases (By similarity). Belongs to the FAM20 family.
      
 0.742
barx1
Homeobox protein BarH-like 1; Transcription factor, is involved in craniofacial development, and in stomach organogenesis; Belongs to the BAR homeobox family.
    
 
 0.621
pax9
Paired box 9.
    
 
 0.598
msx1a
Muscle segment homeobox 1a.
    
 
 0.586
tbx22
T-box transcription factor 22.
      
 0.559
znf706
Zinc finger protein 706.
      
 0.550
pitx2
Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily.
    
 
 0.476
fgf8a
Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis.
    
 
 0.466
bmp4
Bone morphogenetic protein 4.
    
 
 0.458
vps50-2
VPS50 EARP/GARPII complex subunit.
      
 0.456
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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