Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
atf4bActivating transcription factor 4b. (425 aa)    
Predicted Functional Partners:
atf4a
Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity).
  
 
0.995
ddit3
DNA-damage-inducible transcript 3.
   
 0.986
creb1a
cAMP-responsive element-binding protein 1a.
    
 0.984
creb1b
cAMP-responsive element-binding protein 1b.
   
 0.984
atf1
Activating transcription factor 1.
   
 0.976
eif2s1a
Eukaryotic translation initiation factor 2, subunit 1 alpha, like.
    
 0.973
eif2s1b
Eukaryotic translation initiation factor 2, subunit 1 alpha b.
    
 0.971
rps6ka2
Ribosomal protein S6 kinase.
    
 0.956
rps6ka1
Ribosomal protein S6 kinase.
    
 0.956
rps6ka4
Ribosomal protein S6 kinase.
    
 0.951
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (28%) [HD]