Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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tekTyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa)    
Predicted Functional Partners:
angpt1
Angiopoietin 1.
   
 0.999
angpt2a
Angiopoietin 2a.
   
 0.999
angpt4
Angiopoietin 4.
   
 0.999
angpt2b
Angiopoietin 2b.
   
 0.998
vegfc
Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.
   
 0.987
pdgfc
Platelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family.
    
 0.981
pdgfba
Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.
    
 0.977
vegfaa
Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation.
    
 0.976
fgf2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.975
egf
Epidermal growth factor.
    
 0.973
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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