| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000153311 | fancm | ENSDARP00000153311 | ENSDARP00000131968 | Helicase ATP-binding domain-containing protein. | FA complementation group M. | 0.992 |
| ENSDARP00000153311 | her2 | ENSDARP00000153311 | ENSDARP00000055708 | Helicase ATP-binding domain-containing protein. | Hairy-related 2. | 0.603 |
| dla | her15.1 | ENSDARP00000013374 | ENSDARP00000055706 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Hairy and enhancer of split-related 15, tandem duplicate 1. | 0.614 |
| dla | her2 | ENSDARP00000013374 | ENSDARP00000055708 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Hairy-related 2. | 0.464 |
| dla | notch1a | ENSDARP00000013374 | ENSDARP00000137942 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.937 |
| dla | sox19a | ENSDARP00000013374 | ENSDARP00000100683 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Transcription factor Sox-19a; Transcriptional activator. | 0.406 |
| dlb | her2 | ENSDARP00000021660 | ENSDARP00000055708 | Delta-like protein B; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. | Hairy-related 2. | 0.576 |
| dlb | notch1a | ENSDARP00000021660 | ENSDARP00000137942 | Delta-like protein B; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.929 |
| egfra | her2 | ENSDARP00000125265 | ENSDARP00000055708 | Epidermal growth factor receptor precursor. | Hairy-related 2. | 0.504 |
| egfra | notch1a | ENSDARP00000125265 | ENSDARP00000137942 | Epidermal growth factor receptor precursor. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.814 |
| fancm | ENSDARP00000153311 | ENSDARP00000131968 | ENSDARP00000153311 | FA complementation group M. | Helicase ATP-binding domain-containing protein. | 0.992 |
| fancm | her2 | ENSDARP00000131968 | ENSDARP00000055708 | FA complementation group M. | Hairy-related 2. | 0.603 |
| her15.1 | dla | ENSDARP00000055706 | ENSDARP00000013374 | Hairy and enhancer of split-related 15, tandem duplicate 1. | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | 0.614 |
| her15.1 | her15.2 | ENSDARP00000055706 | ENSDARP00000055705 | Hairy and enhancer of split-related 15, tandem duplicate 1. | Zgc:136520 protein. | 0.421 |
| her15.1 | her2 | ENSDARP00000055706 | ENSDARP00000055708 | Hairy and enhancer of split-related 15, tandem duplicate 1. | Hairy-related 2. | 0.488 |
| her15.1 | notch1a | ENSDARP00000055706 | ENSDARP00000137942 | Hairy and enhancer of split-related 15, tandem duplicate 1. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.899 |
| her15.2 | her15.1 | ENSDARP00000055705 | ENSDARP00000055706 | Zgc:136520 protein. | Hairy and enhancer of split-related 15, tandem duplicate 1. | 0.421 |
| her15.2 | her2 | ENSDARP00000055705 | ENSDARP00000055708 | Zgc:136520 protein. | Hairy-related 2. | 0.451 |
| her2 | ENSDARP00000153311 | ENSDARP00000055708 | ENSDARP00000153311 | Hairy-related 2. | Helicase ATP-binding domain-containing protein. | 0.603 |
| her2 | dla | ENSDARP00000055708 | ENSDARP00000013374 | Hairy-related 2. | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | 0.464 |
