Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (334 aa)    
Predicted Functional Partners:
crhb
Corticotropin-releasing hormone b.
    
 0.980
crha
Corticotropin-releasing hormone a.
    
 0.977
ucn3l
Novel protein similar to vertebrate urocortin 3 (Stresscopin) (UCN3).
    
 0.970
uts1
Urotensin 1.
    
 0.955
gnb2
Guanine nucleotide-binding protein (G protein), beta polypeptide 2.
    
  0.930
gnb4b
Guanine nucleotide-binding protein (G protein), beta polypeptide 4b.
    
  0.930
pomca
Pro-opiomelanocortin protein.
   
 0.922
gnb3a
Novel protein similar to guanine nucleotide binding protein (G protein) beta polypeptide family.
    
  0.910
gnb3b
Guanine nucleotide-binding protein (G protein), beta polypeptide 3b.
    
 0.896
gng3
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
   
 0.895
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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