Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
wnt6aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)    
Predicted Functional Partners:
porcn
Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.
    
  0.939
wif1
Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
    
  0.923
notum2
Carboxylesterase notum2; Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling.
    
 0.900
porcnl
Porcupine O-acyltransferase-like; Belongs to the membrane-bound acyltransferase family.
    
  0.896
fzd9b
Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family.
    
  0.891
sfrp5
Secreted frizzled-related protein 5.
    
  0.891
fzd8a
Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.
    
  0.891
fzd3a
Transmembrane receptor frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.
    
  0.891
fzd10
Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.
    
  0.891
fzd3b
Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family.
    
  0.891
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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