Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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isl2bInsulin gene enhancer protein isl-2b; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in the regional specification of the myotome and also in target recognition by the caudal primary neuron. (358 aa)    
Predicted Functional Partners:
elavl3
ELAV-like protein; Belongs to the RRM elav family.
      
 0.782
pou4f3
POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes.
    
 
 0.752
atoh7
Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells.
      
 0.720
lhx4
LIM homeobox 4.
   
 
 0.668
LHX3
LIM/homeobox protein Lhx3.
   
 
 0.668
ldb1b
LIM domain-binding protein 1-A.
    
 
 0.643
znf511
Zinc finger protein 511; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
    
   0.634
mnx2a
Motor neuron and pancreas homeobox 2a.
    
 
 0.604
ltbp3
Latent transforming growth factor beta binding protein 3.
    
 
 0.586
idi1
Isopentenyl-diphosphate delta isomerase 1.
    
   0.582
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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