node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
mfn2 | oma1 | ENSDARP00000123285 | ENSDARP00000119103 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | 0.745 |
mfn2 | parl | ENSDARP00000123285 | ENSDARP00000055977 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Presenilins-associated rhomboid-like protein, mitochondrial. | 0.720 |
mfn2 | pgam5 | ENSDARP00000123285 | ENSDARP00000051620 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity); Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.544 |
mfn2 | phb2a | ENSDARP00000123285 | ENSDARP00000063383 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Prohibitin. | 0.673 |
mfn2 | phb2b | ENSDARP00000123285 | ENSDARP00000022440 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Prohibitin. | 0.625 |
mfn2 | pink1 | ENSDARP00000123285 | ENSDARP00000014981 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | PTEN-induced kinase 1. | 0.995 |
mfn2 | prkn | ENSDARP00000123285 | ENSDARP00000141580 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.996 |
mfn2 | yme1l1b | ENSDARP00000123285 | ENSDARP00000133581 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | YME1-like 1b. | 0.590 |
oma1 | mfn2 | ENSDARP00000119103 | ENSDARP00000123285 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.745 |
oma1 | parl | ENSDARP00000119103 | ENSDARP00000055977 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | Presenilins-associated rhomboid-like protein, mitochondrial. | 0.782 |
oma1 | phb2a | ENSDARP00000119103 | ENSDARP00000063383 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | Prohibitin. | 0.445 |
oma1 | phb2b | ENSDARP00000119103 | ENSDARP00000022440 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | Prohibitin. | 0.453 |
oma1 | pink1 | ENSDARP00000119103 | ENSDARP00000014981 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | PTEN-induced kinase 1. | 0.507 |
oma1 | pmpca | ENSDARP00000119103 | ENSDARP00000132105 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | Peptidase (mitochondrial-processing) alpha; Belongs to the peptidase M16 family. | 0.464 |
oma1 | yme1l1b | ENSDARP00000119103 | ENSDARP00000133581 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | YME1-like 1b. | 0.934 |
parl | mfn2 | ENSDARP00000055977 | ENSDARP00000123285 | Presenilins-associated rhomboid-like protein, mitochondrial. | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.720 |
parl | oma1 | ENSDARP00000055977 | ENSDARP00000119103 | Presenilins-associated rhomboid-like protein, mitochondrial. | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. | 0.782 |
parl | pgam5 | ENSDARP00000055977 | ENSDARP00000051620 | Presenilins-associated rhomboid-like protein, mitochondrial. | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity); Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.839 |
parl | phb2a | ENSDARP00000055977 | ENSDARP00000063383 | Presenilins-associated rhomboid-like protein, mitochondrial. | Prohibitin. | 0.786 |
parl | phb2b | ENSDARP00000055977 | ENSDARP00000022440 | Presenilins-associated rhomboid-like protein, mitochondrial. | Prohibitin. | 0.722 |