| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000132681 | aanat2 | ENSDARP00000132681 | ENSDARP00000002650 | Amine oxidase. | Arylalkylamine N-acetyltransferase 2. | 0.962 |
| ENSDARP00000132681 | ddc | ENSDARP00000132681 | ENSDARP00000005382 | Amine oxidase. | Dopa decarboxylase. | 0.969 |
| ENSDARP00000132681 | ido1 | ENSDARP00000132681 | ENSDARP00000056360 | Amine oxidase. | Indoleamine 2,3-dioxygenase 1. | 0.965 |
| ENSDARP00000132681 | mao | ENSDARP00000132681 | ENSDARP00000032834 | Amine oxidase. | Amine oxidase [flavin-containing]; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta- phenylethylamine (PEA); Belongs to the flavin monoamine oxidase family. | 0.950 |
| ENSDARP00000132681 | tdo2a | ENSDARP00000132681 | ENSDARP00000096367 | Amine oxidase. | Tryptophan 2,3-dioxygenase A; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.412 |
| ENSDARP00000132681 | tdo2b | ENSDARP00000132681 | ENSDARP00000035102 | Amine oxidase. | Tryptophan 2,3-dioxygenase B; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.412 |
| aanat2 | ENSDARP00000132681 | ENSDARP00000002650 | ENSDARP00000132681 | Arylalkylamine N-acetyltransferase 2. | Amine oxidase. | 0.962 |
| aanat2 | asmt | ENSDARP00000002650 | ENSDARP00000139933 | Arylalkylamine N-acetyltransferase 2. | Acetylserotonin O-methyltransferase. | 0.997 |
| aanat2 | ddc | ENSDARP00000002650 | ENSDARP00000005382 | Arylalkylamine N-acetyltransferase 2. | Dopa decarboxylase. | 0.971 |
| aanat2 | ido1 | ENSDARP00000002650 | ENSDARP00000056360 | Arylalkylamine N-acetyltransferase 2. | Indoleamine 2,3-dioxygenase 1. | 0.957 |
| aanat2 | mao | ENSDARP00000002650 | ENSDARP00000032834 | Arylalkylamine N-acetyltransferase 2. | Amine oxidase [flavin-containing]; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta- phenylethylamine (PEA); Belongs to the flavin monoamine oxidase family. | 0.969 |
| afmid | ddc | ENSDARP00000131858 | ENSDARP00000005382 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Dopa decarboxylase. | 0.940 |
| afmid | ido1 | ENSDARP00000131858 | ENSDARP00000056360 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Indoleamine 2,3-dioxygenase 1. | 0.984 |
| afmid | kynu | ENSDARP00000131858 | ENSDARP00000150386 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.995 |
| afmid | tdo2a | ENSDARP00000131858 | ENSDARP00000096367 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Tryptophan 2,3-dioxygenase A; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.987 |
| afmid | tdo2b | ENSDARP00000131858 | ENSDARP00000035102 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Tryptophan 2,3-dioxygenase B; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.970 |
| asmt | aanat2 | ENSDARP00000139933 | ENSDARP00000002650 | Acetylserotonin O-methyltransferase. | Arylalkylamine N-acetyltransferase 2. | 0.997 |
| asmt | cyp1b1 | ENSDARP00000139933 | ENSDARP00000107132 | Acetylserotonin O-methyltransferase. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.951 |
| asmt | ddc | ENSDARP00000139933 | ENSDARP00000005382 | Acetylserotonin O-methyltransferase. | Dopa decarboxylase. | 0.698 |
| asmt | ido1 | ENSDARP00000139933 | ENSDARP00000056360 | Acetylserotonin O-methyltransferase. | Indoleamine 2,3-dioxygenase 1. | 0.958 |
