gbp1 protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
akap12a	gbp1	ENSDARP00000127555	ENSDARP00000056459	A kinase (PRKA) anchor protein 12a.	Guanylate-binding protein 1.	0.560
akap12a	gbp2	ENSDARP00000127555	ENSDARP00000114509	A kinase (PRKA) anchor protein 12a.	Guanylate-binding protein 2.	0.577
caspa	gbp1	ENSDARP00000034228	ENSDARP00000056459	Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...]	Guanylate-binding protein 1.	0.574
caspa	ifnphi1	ENSDARP00000034228	ENSDARP00000033132	Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...]	Interferon phi 1.	0.737
caspa	irf1b	ENSDARP00000034228	ENSDARP00000140878	Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...]	Interferon regulatory factor.	0.629
caspa	nlrp1	ENSDARP00000034228	ENSDARP00000126513	Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...]	NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...]	0.993
furina	gbp1	ENSDARP00000085903	ENSDARP00000056459	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	Guanylate-binding protein 1.	0.541
furina	gbp2	ENSDARP00000085903	ENSDARP00000114509	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	Guanylate-binding protein 2.	0.602
gbp1	akap12a	ENSDARP00000056459	ENSDARP00000127555	Guanylate-binding protein 1.	A kinase (PRKA) anchor protein 12a.	0.560
gbp1	caspa	ENSDARP00000056459	ENSDARP00000034228	Guanylate-binding protein 1.	Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...]	0.574
gbp1	furina	ENSDARP00000056459	ENSDARP00000085903	Guanylate-binding protein 1.	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	0.541
gbp1	gbp2	ENSDARP00000056459	ENSDARP00000114509	Guanylate-binding protein 1.	Guanylate-binding protein 2.	0.800
gbp1	ifi35	ENSDARP00000056459	ENSDARP00000133347	Guanylate-binding protein 1.	Interferon-induced protein 35.	0.532
gbp1	ifnphi1	ENSDARP00000056459	ENSDARP00000033132	Guanylate-binding protein 1.	Interferon phi 1.	0.564
gbp1	irf1b	ENSDARP00000056459	ENSDARP00000140878	Guanylate-binding protein 1.	Interferon regulatory factor.	0.555
gbp1	nlrp1	ENSDARP00000056459	ENSDARP00000126513	Guanylate-binding protein 1.	NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...]	0.565
gbp1	ywhaqa	ENSDARP00000056459	ENSDARP00000062382	Guanylate-binding protein 1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family.	0.581
gbp1	ywhaqb	ENSDARP00000056459	ENSDARP00000022550	Guanylate-binding protein 1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family.	0.581
gbp2	akap12a	ENSDARP00000114509	ENSDARP00000127555	Guanylate-binding protein 2.	A kinase (PRKA) anchor protein 12a.	0.577
gbp2	furina	ENSDARP00000114509	ENSDARP00000085903	Guanylate-binding protein 2.	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	0.602

page 1 of 3

Server load: low (16%) [HD]

Share

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About