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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
skilaSKI-like proto-oncogene a. (623 aa)    
Predicted Functional Partners:
cops9
COP9 signalosome complex subunit 9; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation.
      
 0.868
nadkb
NAD kinase b.
      
 0.866
otos
Otospiralin.
   
  
 0.833
tnk2a
Tyrosine kinase, non-receptor, 2a; Belongs to the protein kinase superfamily. Tyr protein kinase family.
      
 0.807
phc3
Polyhomeotic homolog 3 (Drosophila).
      
 0.806
smad4a
Mothers against decapentaplegic homolog.
   
 0.805
smad3a
Mothers against decapentaplegic homolog.
   
 0.799
smad2
Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis.
   
 0.799
tmtopsb
Teleost multiple tissue opsin b.
    
 
 0.748
gpr160
Similar to Probable G-protein coupled receptor 160.
      
 0.744
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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