STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)    
Predicted Functional Partners:
ptch1
Protein patched homolog 1.
   
 0.999
ptch2
Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family.
   
 0.999
ENSDARP00000125042
Patched 1.
   
 
 0.996
smo
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.989
hhip
Hedgehog-interacting protein.
   
 0.976
boc
BOC cell adhesion-associated, oncogene-regulated.
    
 0.912
cdon
Cell adhesion molecule-related/down-regulated by oncogenes.
    
 0.904
gli2a
GLI family zinc finger 2a.
   
 
 0.884
gli1
GLI family zinc finger 1.
   
 
 0.877
gli3
GLI family zinc finger 3.
   
 
 0.871
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.