| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| chuk | irak1 | ENSDARP00000013115 | ENSDARP00000118154 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Interleukin-1 receptor-associated kinase 1. | 0.985 |
| chuk | irak4 | ENSDARP00000013115 | ENSDARP00000135636 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Interleukin-1 receptor-associated kinase 4. | 0.963 |
| chuk | myd88 | ENSDARP00000013115 | ENSDARP00000020711 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.875 |
| chuk | tab1 | ENSDARP00000013115 | ENSDARP00000053182 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.981 |
| chuk | tirap | ENSDARP00000013115 | ENSDARP00000103037 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. | 0.597 |
| chuk | tnfaip3 | ENSDARP00000013115 | ENSDARP00000123481 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Tumor necrosis factor, alpha-induced protein 3. | 0.678 |
| chuk | traf4b | ENSDARP00000013115 | ENSDARP00000056877 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | TNF receptor-associated factor. | 0.899 |
| ecsit | irak4 | ENSDARP00000124710 | ENSDARP00000135636 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | Interleukin-1 receptor-associated kinase 4. | 0.698 |
| ecsit | myd88 | ENSDARP00000124710 | ENSDARP00000020711 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.494 |
| ecsit | traf4b | ENSDARP00000124710 | ENSDARP00000056877 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | TNF receptor-associated factor. | 0.913 |
| edaradd | traf4b | ENSDARP00000084349 | ENSDARP00000056877 | EDAR-associated death domain. | TNF receptor-associated factor. | 0.887 |
| irak1 | chuk | ENSDARP00000118154 | ENSDARP00000013115 | Interleukin-1 receptor-associated kinase 1. | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | 0.985 |
| irak1 | irak4 | ENSDARP00000118154 | ENSDARP00000135636 | Interleukin-1 receptor-associated kinase 1. | Interleukin-1 receptor-associated kinase 4. | 0.997 |
| irak1 | myd88 | ENSDARP00000118154 | ENSDARP00000020711 | Interleukin-1 receptor-associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. | 0.999 |
| irak1 | tab1 | ENSDARP00000118154 | ENSDARP00000053182 | Interleukin-1 receptor-associated kinase 1. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.973 |
| irak1 | tirap | ENSDARP00000118154 | ENSDARP00000103037 | Interleukin-1 receptor-associated kinase 1. | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. | 0.994 |
| irak1 | tnfaip3 | ENSDARP00000118154 | ENSDARP00000123481 | Interleukin-1 receptor-associated kinase 1. | Tumor necrosis factor, alpha-induced protein 3. | 0.447 |
| irak1 | traf4b | ENSDARP00000118154 | ENSDARP00000056877 | Interleukin-1 receptor-associated kinase 1. | TNF receptor-associated factor. | 0.928 |
| irak4 | chuk | ENSDARP00000135636 | ENSDARP00000013115 | Interleukin-1 receptor-associated kinase 4. | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | 0.963 |
| irak4 | ecsit | ENSDARP00000135636 | ENSDARP00000124710 | Interleukin-1 receptor-associated kinase 4. | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B. | 0.698 |
