| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aacs | bdh2 | ENSDARP00000002180 | ENSDARP00000069085 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.734 |
| aacs | hmgcl | ENSDARP00000002180 | ENSDARP00000026028 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.966 |
| aacs | hmgcll1 | ENSDARP00000002180 | ENSDARP00000133158 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.962 |
| aacs | oxct1a | ENSDARP00000002180 | ENSDARP00000002234 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.931 |
| aacs | oxct1b | ENSDARP00000002180 | ENSDARP00000074184 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.938 |
| aacs | zgc:113054 | ENSDARP00000002180 | ENSDARP00000070003 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Zgc:113054. | 0.734 |
| aacs | zgc:113142 | ENSDARP00000002180 | ENSDARP00000056885 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Zgc:113142; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.964 |
| bdh2 | aacs | ENSDARP00000069085 | ENSDARP00000002180 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.734 |
| bdh2 | hmgcl | ENSDARP00000069085 | ENSDARP00000026028 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.682 |
| bdh2 | hmgcll1 | ENSDARP00000069085 | ENSDARP00000133158 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.682 |
| bdh2 | oxct1a | ENSDARP00000069085 | ENSDARP00000002234 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.635 |
| bdh2 | oxct1b | ENSDARP00000069085 | ENSDARP00000074184 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.635 |
| bdh2 | zgc:113142 | ENSDARP00000069085 | ENSDARP00000056885 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | Zgc:113142; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.785 |
| cyp19a1a | zgc:113142 | ENSDARP00000111604 | ENSDARP00000056885 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Zgc:113142; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.626 |
| hmgcl | aacs | ENSDARP00000026028 | ENSDARP00000002180 | 3-hydroxy-3-methylglutaryl-CoA lyase. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.966 |
| hmgcl | bdh2 | ENSDARP00000026028 | ENSDARP00000069085 | 3-hydroxy-3-methylglutaryl-CoA lyase. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.682 |
| hmgcl | hmgcll1 | ENSDARP00000026028 | ENSDARP00000133158 | 3-hydroxy-3-methylglutaryl-CoA lyase. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.944 |
| hmgcl | oxct1a | ENSDARP00000026028 | ENSDARP00000002234 | 3-hydroxy-3-methylglutaryl-CoA lyase. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.937 |
| hmgcl | oxct1b | ENSDARP00000026028 | ENSDARP00000074184 | 3-hydroxy-3-methylglutaryl-CoA lyase. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.937 |
| hmgcl | zgc:113054 | ENSDARP00000026028 | ENSDARP00000070003 | 3-hydroxy-3-methylglutaryl-CoA lyase. | Zgc:113054. | 0.682 |
