Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
nfybaNuclear transcription factor Y, beta a. (204 aa)    
Predicted Functional Partners:
nfyc
Nuclear transcription factor Y, gamma.
   
 0.999
nfya
Nuclear transcription factor Y, alpha.
   
 0.969
nfyal
Nuclear transcription factor Y, alpha,-like.
   
 0.969
nfybb
Nuclear transcription factor Y, beta b.
  
  
 
0.900
ciita
Class II, major histocompatibility complex, transactivator.
     
 0.883
chrac1
Chromatin accessibility complex subunit 1.
   
 0.863
pole4
Polymerase (DNA-directed), epsilon 4, accessory subunit.
    
 
 0.844
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
    
   0.747
im:7138239
Im:7138239.
   
 0.651
ep300b
E1A-binding protein p300 b.
    
 
 0.643
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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