Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
igfbp5aInsulin-like growth factor-binding protein 5a. (268 aa)    
Predicted Functional Partners:
igf2a
Insulin-like growth factor 2a.
   
 0.928
igf2b
Insulin-like growth factor 2b.
   
 0.920
pappaa
Pregnancy-associated plasma protein A, pappalysin 1a.
    
 
 0.842
igf1
Insulin-like growth factor 1b.
     
 0.818
pappab
Pregnancy-associated plasma protein A, pappalysin 1b.
    
 
 0.744
ghra
Growth hormone receptor a.
   
  
 0.727
pappa2
Pappalysin 2.
    
 
 0.718
stc2b
Stanniocalcin 2b.
      
 0.668
trpv6
Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.662
igf1ra
Tyrosine-protein kinase receptor.
   
 
 0.606
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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