node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F1QVK9_DANRE | ska1 | ENSDARP00000122228 | ENSDARP00000057512 | Si:dkeyp-20g2.3. | Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] | 0.864 |
cdc20 | cenpe | ENSDARP00000140575 | ENSDARP00000099552 | Cell division cycle 20 homolog. | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.946 |
cdc20 | espl1 | ENSDARP00000140575 | ENSDARP00000128879 | Cell division cycle 20 homolog. | Extra spindle pole bodies-like 1, separase. | 0.924 |
cdc20 | kif11 | ENSDARP00000140575 | ENSDARP00000006884 | Cell division cycle 20 homolog. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.953 |
cdc20 | ndc80 | ENSDARP00000140575 | ENSDARP00000012236 | Cell division cycle 20 homolog. | Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] | 0.943 |
cdc20 | nuf2 | ENSDARP00000140575 | ENSDARP00000040811 | Cell division cycle 20 homolog. | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. | 0.927 |
cdc20 | plk1 | ENSDARP00000140575 | ENSDARP00000075786 | Cell division cycle 20 homolog. | Serine/threonine-protein kinase PLK. | 0.993 |
cdc20 | ska1 | ENSDARP00000140575 | ENSDARP00000057512 | Cell division cycle 20 homolog. | Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] | 0.909 |
cdc20 | ska2 | ENSDARP00000140575 | ENSDARP00000153338 | Cell division cycle 20 homolog. | Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] | 0.803 |
cdc20 | ska3 | ENSDARP00000140575 | ENSDARP00000116579 | Cell division cycle 20 homolog. | Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the p [...] | 0.419 |
cenpe | cdc20 | ENSDARP00000099552 | ENSDARP00000140575 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Cell division cycle 20 homolog. | 0.946 |
cenpe | espl1 | ENSDARP00000099552 | ENSDARP00000128879 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Extra spindle pole bodies-like 1, separase. | 0.893 |
cenpe | kif11 | ENSDARP00000099552 | ENSDARP00000006884 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.982 |
cenpe | ndc80 | ENSDARP00000099552 | ENSDARP00000012236 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] | 0.940 |
cenpe | nuf2 | ENSDARP00000099552 | ENSDARP00000040811 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. | 0.967 |
cenpe | plk1 | ENSDARP00000099552 | ENSDARP00000075786 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Serine/threonine-protein kinase PLK. | 0.946 |
cenpe | ska1 | ENSDARP00000099552 | ENSDARP00000057512 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] | 0.875 |
cenpe | ska3 | ENSDARP00000099552 | ENSDARP00000116579 | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the p [...] | 0.603 |
espl1 | cdc20 | ENSDARP00000128879 | ENSDARP00000140575 | Extra spindle pole bodies-like 1, separase. | Cell division cycle 20 homolog. | 0.924 |
espl1 | cenpe | ENSDARP00000128879 | ENSDARP00000099552 | Extra spindle pole bodies-like 1, separase. | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.893 |