Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ch25hl1.1Cholesterol 25-hydroxylase-like protein 1, member 1; May catalyze the formation of 25-hydroxycholesterol from cholesterol. (282 aa)    
Predicted Functional Partners:
sc5d
Sterol-C5-desaturase; Belongs to the sterol desaturase family.
   
 0.942
cyp7b1
Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.
   
 0.926
cyp7a1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 0.926
cyp51
Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
   
 0.923
hsd17b7
Hydroxysteroid (17-beta) dehydrogenase 7.
   
 0.890
nsdhl
NAD(P)-dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.
   
 0.878
sqleb
Squalene epoxidase b.
   
 0.866
sqlea
Squalene epoxidase a.
   
 0.866
cyp39a1
Cytochrome P450, family 39, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.
   
 0.860
dhcr7
7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
   
 0.851
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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