Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
il22ra2Interleukin 22 receptor, alpha 2. (238 aa)    
Predicted Functional Partners:
crfb16
Cytokine receptor family member B16.
     
 0.983
il10
Interleukin-10.
     
 0.963
jak1
Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.
     
  0.962
crfb4
Cytokine receptor family member b4.
    
 0.941
il20ra
Interleukin 20 receptor, alpha.
  
  
0.932
il10rb
Interleukin 10 receptor, beta.
    
 0.927
stat4
Signal transducer and activator of transcription.
   
 0.849
stat6
Signal transducer and activator of transcription.
    
 0.841
stat1a
Signal transducer and activator of transcription.
    
 0.822
stat2
Signal transducer and activator of transcription.
    
 0.822
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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