STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ier3ip1Immediate early response 3-interacting protein 1; May be involved in protein transport between endoplasmic reticulum and Golgi apparatus; Belongs to the YOS1 family. (82 aa)    
Predicted Functional Partners:
sostdc1a
Sclerostin domain-containing 1a.
      
 0.806
wdr26b
WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the b [...]
   
  
 0.650
tmem167a
Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.
   
   0.643
hdhd2
Haloacid dehalogenase-like hydrolase domain-containing protein 2.
   
  
 0.633
trmt10a
tRNA methyltransferase 10A.
   
  
 0.599
yipf6
Protein YIPF6.
   
  
 0.595
tubgcp4
Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.
      
 0.594
spint1b
Serine peptidase inhibitor, Kunitz type 1 b.
      
 0.584
nsmce2
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.
      
 0.582
rabac1
PRA1 family protein.
   
  
 0.572
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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