STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (566 aa)    
Predicted Functional Partners:
fbxw4
F-box and WD repeat domain-containing 4.
 
 
  
 0.867
wdr11
WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles.
      
 0.867
xrcc1
X-ray repair-complementing defective repair in Chinese hamster cells 1.
   
 
 0.853
lig4
DNA ligase.
  
 0.821
rev3l
REV3-like, DNA directed polymerase zeta catalytic subunit.
   
 
 0.774
xrcc6
X-ray repair-complementing defective repair in Chinese hamster cells 6.
   
 0.750
kazald3
Kazal-type serine peptidase inhibitor domain 3.
      
 0.742
tdp1
Tyrosyl-DNA phosphodiesterase 1.
   
 
 0.710
xrcc5
X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.
   
 
 0.705
prkdc
Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.
   
 
 0.701
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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