Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
zgc:172182Coiled-coil domain-containing protein 89; Belongs to the CCDC89 family. (354 aa)    
Predicted Functional Partners:
snf8
Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity).
      
 0.882
fbxo38
F-box protein 38.
      
 0.861
appbp2
Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.
      
 0.852
necab1
N-terminal EF-hand calcium-binding protein 1.
      
 0.834
dcaf12
DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
      
 0.828
klhl15
Kelch-like protein 15; Substrate-specific adapter for an E3 ubiquitin-protein ligase complex.
      
 0.789
gmcl1
Germ cell-less, spermatogenesis-associated.
      
 0.762
fem1b
Fem-1 homolog b.
      
 0.708
fnip1
Folliculin-interacting protein 1.
      
 0.689
trpc4a
Transient receptor potential cation channel, subfamily C, member 4a; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.662
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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