Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
zp3bZona pellucida glycoprotein 3b. (532 aa)    
Predicted Functional Partners:
gipr
Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.
    
  0.853
calcr
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
    
  0.853
ghrhrl
Growth hormone-releasing hormone receptor,-like; Belongs to the G-protein coupled receptor 2 family.
    
  0.853
crhr1
Corticotropin-releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family.
    
  0.853
gper1
G-protein coupled estrogen receptor 1; Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes.
    
  0.847
agtr1a
Angiotensin II receptor, type 1a; Belongs to the G-protein coupled receptor 1 family.
    
  0.839
oxtr
Isotocin receptor-like 2; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
    
  0.839
ghsrb
Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.
    
  0.839
tshr
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
    
  0.834
lhcgr
Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
    
  0.834
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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