Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ckmt2bCreatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa)    
Predicted Functional Partners:
gamt
Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
     
 0.926
got2b
Aspartate aminotransferase.
    
 
 0.897
vdac1
Voltage-dependent anion channel 1.
    
 0.881
got2a
Aspartate aminotransferase.
    
 
 0.871
got1
Aspartate aminotransferase.
   
 
 0.867
mb
Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
   
 
 0.823
myog
Myogenin.
   
 
 0.787
ckmb
Creatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family.
  
0.751
slc25a4
Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family.
   
 
 0.740
gatm
Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).
    
 0.736
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.